Only tranilast, but not the other anti-allergic drugs, possesses angiotensin II antagonism
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چکیده
منابع مشابه
Anti-Allergic Drugs Tranilast and Ketotifen Dose-Dependently Exert Mast Cell-Stabilizing Properties.
BACKGROUND Anti-allergic drugs, such as tranilast and ketotifen, inhibit the release of chemokines from mast cells. However, we know little about their direct effects on the exocytotic process of mast cells. Since exocytosis in mast cells can be monitored electrophysiologically by changes in the whole-cell membrane capacitance (Cm), the absence of such changes by these drugs indicates their mas...
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Functional and structural changes of chronic renal allograft failure share similarities with other chronic nephropathies with low nephron number. In models of reduced nephron number, angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers prevented proteinuria and retarded renal lesions. This study investigates whether blockade of angiotensin II activity prevented chronic a...
متن کاملThree distinct anti-allergic drugs, amlexanox, cromolyn and tranilast, bind to S100A12 and S100A13 of the S100 protein family.
To investigate the roles of calcium-binding proteins in degranulation, we used three anti-allergic drugs, amlexanox, cromolyn and tranilast, which inhibit IgE-mediated degranulation of mast cells, as molecular probes in affinity chromatography. All of these drugs, which have different structures but similar function, scarcely bound to calmodulin in bovine lung extract, but bound to the same kin...
متن کاملOn Endogenous Angiotensin II Antagonism in Hypertension
During the past 40 years, most of the new developed and effective antihypertensive drugs target the classic renin– angiotensin–aldosterone system (RAAS) by blocking receptors (such as the mineralocorticoid receptor or the angiotensin II type 1 receptor) and also by inhibiting enzymes within the angiotensin II (Ang II) formation pathway, such as the angiotensin-converting enzyme I (ACE I) and re...
متن کاملOn Endogenous Angiotensin II Antagonism in Hypertension
During the past 40 years, most of the new developed and effective antihypertensive drugs target the classic renin– angiotensin–aldosterone system (RAAS) by blocking receptors (such as the mineralocorticoid receptor or the angiotensin II type 1 receptor) and also by inhibiting enzymes within the angiotensin II (Ang II) formation pathway, such as the angiotensin-converting enzyme I (ACE I) and re...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1998
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)40971-2